In New York City, teenager Clary Fray (Lily Collins) begins seeing a strange symbol, worrying her mother Jocelyn Fray (Lena Headey) and her mother's friend Luke Garroway (Aidan Turner). Later, while attending a nightclub with her best and only friend Simon Lewis (Robert Sheehan), Clary witnesses the murder of a man by the hands of Jace Wayland (Jamie Campbell Bower), whom appears only Clary is able to see. Meanwhile, Jocelyn is abducted by two men, Emil Pangborn (Kevin Durand) and Samuel Blackwell (Robert Maillet), and they leave a message for Clary warning her that someone named Valentine is coming after her, then drinks a potion that leaves her in a comatose state. Returning home, Clary is attacked by a demon and rescued by Jace, who reveals himself to be a Shadowhunter, a warrior trained to slay demons hidden on Earth, such as the man in the nightclub. Jocelyn was a Shadowhunter as well, and Clary has inherited her powers, including the ability to use runes.Clary and Jace visit Clary's neighbor and friend of her mother, Madame Dorothea (C. C. H. Pounder), a witch who deduces that Pangborn and Blackwell are after the Mortal Cup, one of the three Mortal Instruments given to the first Shadowhunter by the Angel Raziel, that allows normal humans to become half-Angel Shadowhunters. Simon, now able to see Jace, joins them as they leave to meet Luke in his bookstore. There, they discover that Luke is being interrogated by Pangborn and Blackwell, stating that he cares nothing for Jocelyn, and is after the Mortal Cup himself. The trio then escapes to the Shadowhunters' base of operations, the Institute, where Clary and Simon meet Jace's fellow Shadowhunters, Alec Lightwood (Kevin Zegers) and Isabelle Lightwood (Jemima West), and their leader, Hodge Starkweather (Jared Harris), who reveals that Pangborn and Blackwell are working for Valentine Morgenstern (Jonathan Rhys Meyers), an ex-Shadowhunter who betrayed the race of the Nephilim and sought to steal the Mortal Cup to gain control over all Shadowhunters and demons.
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